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I was wondering can I upgrade my 16gb 4g new iPad into a apple store and get a 32gb and how much would it cost me ? |
If youre outisde that window, then there's no such thing as upgrading. You'd be buying a whole new iPad.
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Be kind to yourself. Practice self-acceptance. 16g AT&T 4G iPad, 2011 11" MBA, Apple Tv, AT&T Galaxy Note
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Justin Bieber gets slimed after accepting the award for favorite male singer onstage at Nickelodeon's 25th Annual Kids' Choice Awards on Saturday, March 31, 2012 in Los Angeles. (AP Photo/Chris Pizzello)
Justin Bieber gets slimed after accepting the award for favorite male singer onstage at Nickelodeon's 25th Annual Kids' Choice Awards on Saturday, March 31, 2012 in Los Angeles. (AP Photo/Chris Pizzello)
Heidi Klum, left, and Chris Colfer get slimed as they present the award for favorite TV actress at Nickelodeon's 25th Annual Kids' Choice Awards on Saturday, March 31, 2012 in Los Angeles. (AP Photo/Chris Pizzello)
Host Will Smith performs at Nickelodeon's 25th Annual Kids' Choice Awards on Saturday, March 31, 2012 in Los Angeles. (AP Photo/Chris Pizzello)
First lady Michelle Obama attends Nickelodeon's 25th Annual Kids' Choice Awards on Saturday, March 31, 2012 in Los Angeles. (AP Photo/Chris Pizzello)
Al Roker arrives at Nickelodeon's 25th Annual Kids' Choice Awards on Saturday, March 31, 2012 in Los Angeles. (AP Photo/Chris Pizzello)
At the 25th annual Kids' Choice Awards, the slime runneth over.
Host Will Smith opened the 25th annual Kids' Choice Awards promising a record amount of the show's trademark green gunk. Though some 20 awards are presented at the KCAs, the real suspense isn't who will take home a "Blimp" (the show's Oscar), it's when and on whom the slime will spill.
It's like a baptism into kid-dome that can come at any moment: from a hidden bucket, dumped from the rafters or exploded from little orange blimps.
"No one is safe from the slime!" screamed Smith. "You have to earn the slime! It's an honor."
Halle Berry was the first to be covered, but she was far from alone. She was joined by "Twilight" star Taylor Lautner (who won favorite "buttkicker"), "Glee" star Chris Colfer and male singer winner Justin Bieber, who was utterly drenched along with Smith at the end of the show.
The KCAs are Nickelodeon's annual celebration for kids, and it's often the most-watched children's program of the year. They draw a considerable roster of stars looking to thank their smallest fans and cater to their youngest demographics.
"This is, like, the coolest award show ever," said "Twilight" star Kristen Stewart, accepting the award for favorite movie actress.
Smith, himself a 10-time Blimp winner, started the show with an elaborate, digitally-animated skydive from Nickelodeon's trademark blimp. Smith was then hoisted from the rafters to the stage of the Galen Center at the University of Southern California in Los Angeles, where thousands of glow-stick waving fans cheered him ? including first lady Michelle Obama.
Obama later presented "the big help" award for charity work to Taylor Swift. Upon receiving the award, the pop star said, "I am freaking out."
Nickelodeon introduces many kid-friendly quirks to the usual award show festivities. It rolls out an orange carpet, rather than a red one, and envelopes are the last way winners are announced. Saturday night's choices came by way of a sword eater, a statue impersonator and giant heads held aloft from the crowd.
Winners are chosen from voting online. Selena Gomez won for both favorite TV actress and female singer. Adam Sandler took home the award for favorite movie actor. And Katy Perry, shortly after performing, was given the award for favorite voice in an animated movie for "Smurfs."
"The only reason why I'm still here today ? and remember this ? is because I've never grown up!" Perry told the young audience.
More than 7.3 million watched last year's awards. This year, Nickelodeon badly needs the KCAs to continue such a success. In March, for the first time, the Disney Channel beat out Nickelodeon in average total daily viewers ? a title Nickelodeon had held every month since 1995.
Nickelodeon's own series "Victorious" won best TV show. Jake Short, star of the Disney Channel's "A.N.T. Farm," won best TV actor.
But the most ceremonious moment of the KCAs is the slimey finale. The honor ? which Smith said had been chosen by online votes ? went to Bieber, who made a surprise appearance late in the show. Smith clutched Bieber as fountains of slime poured out across the stage, while Obama ? splattered by a few drops ? danced in the seats.
___
Online:
http://www.nick.com/KCA12
Associated Presslos angeles angels los angeles angels lindsay lohan’s playboy cover leaked online lindsay lohan’s playboy cover leaked online va tech shooting 2011 cj wilson coriolanus
By Frank Mason, on March 31st, 2012
Lady Gaga has been diagnosed with brain cancer.
Los Angeles - It is our sad duty to report American pop idol Lady Gaga has been diagnosed with brain cancer.
A Saturday announcement confirmed physicians discovered what has been called an ?inoperable? malignant tumor in the brain of?Stefani Joanne Angelina Germanotta, perhaps known better as Lady Gaga, after the singer complained of feeling more run down and fatigued than usual.
Lady Gaga is being treated at the Cedars-Sinai medical institution. She thanked her fans for their support in this difficult time, encouraging everyone to ?stay strong,? reassuring the public she ?will persevere.?
Germanotta?s agent requested media and fans to contact Lady Gaga, as usual, care of her record labels, Def Jam Records, and Interscope.
Lady Gaga stopped using cell phones two years ago because of paranoia that they might cause brain cancer. Saturday?s news indicates she may not have stopped soon enough.
There has been no word yet as to whether the Born This Way Ball Tour (on The Road To Love) will continue as scheduled.
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? Job Search Techniques - New Bedford Instructor will present a variety of job search techniques and how they can be strengthened by workshops offered at the career center. Monday, 02 April, 2012 Categories: ? |
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Genentech has been saying for years that it has confidence in a?supercharged version of its hit breast cancer drug, and today it cleared a?major hurdle on the way to making it?a?reality.
The South San Francisco-based company, a?unit of Roche, said today that trastuzumab emtansince (T-DM1) passed its biggest clinical trial yet, a?study of 991 women with metastatic breast cancer that overexpresses the HER2 protein, and who have previously been treated with the original trastuzumab (Herceptin) and a?taxane chemotherapy. The trial, called Emilia, randomly assigned women to get either T-DM1 or a?combination of GlaxoSmithKline?s lapatinib (Tykerb) and a?chemo drug called capecitabine (Xeloda).
Full details weren?t released today, but Genentech said its new drug met the study?s goal, keeping tumors from spreading for a?significantly longer time than the drugs in the control group. Safety results were consistent with what was seen in prior studies, the company said. Even though the company hasn?t yet followed patients long enough to see if the new drug can extend lives, Genentech said the data was compelling enough for the company to file an application seeking FDA approval of T-DM1 this year, and Roche plans to do the same in Europe. About 229,000 women in the U.S. are diagnosed with breast cancer each year, and the new drug, if approved, could be a?potent new option for about one-fourth of patients whose tumors overexpress the HER2?protein.
?While prior data clearly showed the efficacy and safety of T-DM1 in both first and third line breast cancer, no data was previously available to directly compare the efficacy of T-DM1 to Tykerb/Xeloda,? said Jason Kantor, an analyst with RBC Capital Markets, in a?note to clients today. ?While we believe most investors assume EMILIA would be positive, for us, the results are an important derisking?event.?
T-DM1 is interesting not only for breast cancer patients, but for scientists, because of its unusual way of attacking cancer cells. Genentech has had huge success over the years with its original antibody, trastuzumab (Herceptin), which precisely targets the HER2 protein. But scientists there, along with collaborators at Waltham, MA-based ImmunoGen, believed they could give the drug even more tumor-killing punch if they could attach a?potent toxin to the antibody, making it sort of like a?heat-seeking missile.
Genentech previously sought FDA approval on a?smaller body of evidence from mid-stage clinical trials, and was turned down in August 2010. Since then, Genentech has beefed up the body of evidence for the drug, showing T-DM1 beat its own original product in a?head-to-head study of 137 patients, in addition to the results from today?s bigger Emilia study. And the company isn?t stopping there, running two more Phase III clinical trials of T-DM1 in a?couple different?settings.
Even though Genentech is responsible for development, and will keep the vast majority of product revenues for itself, today?s result is an important moment for ImmunoGen. The company stands to collect a ?mid-single digit? percentage royalty on worldwide sales from T-DM1, because of its contribution to help link the antibody to the toxin. ImmunoGen has no products of its own on the market, and the approval of T-DM1 would provide a?significant percentage from a?potential multi-billion dollar?seller.
Shares of ImmunoGen (NASDAQ: IMGN) climbed 9?percent to $15 at 10:19 am Eastern?time.
Luke Timmerman is the National Biotech Editor of Xconomy. E-mail him at ltimmerman@xconomy.com or follow him on Twitter at @ldtimmerman.
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